Solid organ transplantation 10-15 mg/kg/day in 2 divided doses, initiated 12 hr pre-op & continued 1-2 wk post-op. Gradually reduce dose to 2-6 mg/kg in 2 divided doses.
Bone marrow transplantation Initially 3-5 mg/kg/day IV infusion for up to 2 wk, then shift to oral therapy w/ Sandimmun Neoral 12.5 mg/kg/day in 2 divided doses for 3-6 mth.
Endogenous uveitis Initially 5 mg/kg/day orally in 2 divided doses; may be increased to 7 mg/kg/day for a limited period. To achieve initial remission or to counteract inflammatory ocular attacks, systemic corticosteroid treatment w/ prednisolone 0.5-0.6 mg/kg/day or an equiv may be added if Sandimmun Neoral alone is insufficient to control the situation. Maintenance: Slowly reduce dose to the lowest effective level which, during the remission phases, should not exceed 5 mg/kg/day.
Psoriasis Initially 2.5 mg/kg/day given orally in 2 divided doses. If no improvement after 1 mth, the dose may be increased but should not exceed 5 mg/kg/day.
RA 2.5 mg/kg/day in 2 divided doses for the 1st 6 wk of treatment. Max: 4 mg/kg.
Nephrotic syndrome Adult 5 mg/kg/day in 2 divided doses.
Childn 6 mg/kg/day in 2 divided doses.
Renal impairment Initial dose should not exceed 2.5 mg/kg.
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